真菌（真核生物）和 细菌（原核生物）的 P450 催化系统有所不同，这也导致了对原核生物 P450s 的功能、结构和机理研究的蓬勃发展，而对真菌 P450s 的相应研究则受到很大限制。具体来说，第一，膜结合的性质使得真菌 P450s 和 CPRs 难以异源表达，特别是通过大肠 ...

Agriculture, School of Natural and Environmental Sciences, Newcastle University, Newcastle upon Tyne NE1 7RU, U.K. Syngenta, Jealott’s Hill, Bracknell, Berkshire ...

The aromatic backbone of thymol and carvacrol is formed by P450 monooxygenases in combination with a dehydrogenase via an unstable intermediate. Additional P450s hydroxylate thymol and carvacrol to ...

Cytochrome P450s (CYPs) and UDP-glucuronosyltransferases (UGTs) are both greatly important metabolic enzymes in various tissues, including brain. Although expressions of brain CYPs and UGTs and their ...

Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Innovation Academy for South China Sea Ecology ...

Cytochrome P450 monooxygenases (P450s) represent the largest enzyme family of the plant metabolism. Plants typically devote about 1% of the protein-coding genes for the P450s to execute primary ...

Cytochrome P450s are a superfamily of heme-dependent enzymes that fulfil a broad range of critical functions across all domains of life 1.In humans, liver P450s are responsible for the metabolism ...

ABSTRACT: Background: The human serine palmitoyltransferase-1, SPTLC1, subunit is emerging as a stress responsive protein with putative role in modulating cellular stress response behavior. When ...

ABSTRACT: The aim of this study was to characterize CYP1A1 and CYP3A in liver of the Kafue lechwe from Lochnivar and Blue Lagoon GMAs and to determine their mRNA expression levels as potential ...