Cytochrome P450 enzymes (P450s) are a diverse group of heme-containing enzymes that play a crucial role in the metabolism of various substances, including drugs and natural products. They are ...

Cytochrome P450 enzymes (CYPs) are a large family of enzymes that play a crucial role in the metabolism of various substances, including drugs and xenobiotics (foreign compounds). In cancer ...

Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States Department of Chemistry, Massachusetts Institute of Technology, Cambridge, ...

There is evidence that enhanced metabolism often involves multiple genes from different herbicide detoxifying-enzyme families, such as cytochrome P450 monooxygenases (P450s), glutathione ...

A growing body of evidence links use of proton pump inhibitors to kidney problems, including kidney failure in patients with existing CKD.

Objective: The cytochrome P450 2D6 (CYP2D6) is an enzyme involved in the oxidative biotransformation of various widely used drugs, including paroxetine, a substrate and strong inhibitor of the enzyme.

Microbial factories provide a sustainable alternative to tree sap for producing elusive plant molecules, offering new ...

Grapefruit juice, a health food staple, can interact with statins, rheumatoid arthritis drugs and psoriasis treatments.

A new technology is poised to transform the discovery of microbial species and enzymes with specific in situ metabolic ...

Nutritious foods aren’t always harmless. Grapefruit juice, greens, and other staples can disrupt medications. Discover five ...

The same study also found that taurine reduced the resistance of blood flow in the blood vessel walls and enhanced the ...

is a substrate of cytochrome P450 (CYP)2C8, CYP2C9, and CYP3A4, and to a minor extent, CYP2C19 and CYP2J2. ETR has the potential for drug-drug interaction (DDI) with CYP2C8, CYP2C9, and CYP3A4 when ...