AA is metabolized to biological mediators by three enzymatic pathways: cyclooxygenase, lipoxygenase, and cytochrome P450. Each pathway contains enzyme-specific steps that result in a wide variety of ...

Daily-phased metabolites reached peak metabolic abundance mainly at dawn (Zeitgeber time 2 (ZT2, zeitgeber time relative to this experimental LD cycle, and in an LD cycle of 12h of light and ...

75 Sildenafil and tadalafil are reversible competitive inhibitors of the catalytic domain of PDE-5 involved in the hydrolysis of cGMP ... which can then enter the Krebs cycle to initiate normal ...