Of all the aminos tested, knocking out cysteine led to rapid and drastic weight loss, reducing some of the rodents' body weights by 30% in just seven days. The reason for the result was that when ...

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BioComp Group, Institute of Advanced Materials (INAM), Universitat Jaume I, 12071 Castelló, Spain ...

(95,96) The rationale for targeting cysteines is clear but not every protein pocket contains an available cysteine, prompting exploration of electrophilic groups that can ligand sites beyond cysteine.

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