4a) were similar to those for template A (Fig. 2a). Figure 4: Conformational profiles depend on the templating base. Whereas the unliganded wt KF, E710A and E710Q polymerases exhibit similar ...

This useful manuscript describes cryo-EM structures of archaeal proteasomes that reveal insights into how occupancy of binding pockets on the 20S protease regulates proteasome gating. The evidence ...

However, when testing a hydrogenated derivative – specifically 18,19-dihydro salinomycin – they managed to replace a C–H bond ...

In biology, enzymes have evolved over millions of years to drive chemical reactions. Scientists from the Max Planck Institute ...

as well as ionizable functional groups effecting successful cell permeability. PCA (Protein Conformational Array) technology can quantify conformational change by measuring protein surface epitope ...

In biology, enzymes have evolved over millions of years to drive chemical reactions. Scientists have now derived universal rules to enable the de novo design of optimal enzymes. As an example, they ...

Conformational changes in proteins, which occur at the nanoscale, are fundamental to processes ranging from enzyme catalysis and chemical signaling to cell division and differentiation.

Researchers led by Université de Montréal pathology and cell-biology professor Marc Therrien have identified major structural ...

Unlike chemical reactions, biomolecular conformational changes, such as protein folding or binding to other molecules, involve multiple metastable intermediate states, giving rise to numerous ...

The parameters that can be determined include the following: The Zetasizer Helix (ZS Helix) from Malvern Panalytical combines a fiber-coupled Raman spectrometer with a Zetasizer Nano ZSP to provide ...

Recently, a research team has collaborated to propose a deep learning model for predicting protein conformational changes. This achievement has been published online in Advanced Science.