CANTON, Mass.--(BUSINESS WIRE)-- Conformation-X Therapeutics, LLC, an immune-oncology focused drug development company, announced today that it has closed an oversubscribed funding tranche of $3.65M, ...

SARS-CoV-2 spike protein plays a key role in mediating viral entry and inducing host immune responses. It can adopt either an open or closed conformation based on the position of its receptor-binding ...

All circulating variants of concern (VOCs) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 ... in equilibrium including an open conformation, where the RBD freely bonded ...

There are three prefusion conformations for SARS-CoV-2 — two of which are shared with another coronavirus called SARS-CoV-1 S. However, the locked conformation is new, and there are limited data ...

In this study, we examine the orientation of components of the scaffold and establish that the conformation of the inner ring of the NPC is modulated by ... The strength of mEGFP excitation is ...

Similar EC1 mutations in CD81 impairs the accurate glycosylation of CD19. Here, we report the 2.9 Å structure of CD53 in the open conformation. Unexpectedly, the transmembrane domain of CD53 without ...

The inactive conformations of glucagon receptor (GCGR) are widely reported by crystal structures that support the precision structure for drug discovery of type 2 diabetes. The previous study shows ...

This suggests that the R-enantiomer can form intermolecular hydrogen bonds most effectively than the S-enantiomer, explaining the week binding of the S-enantiomer at pH 2.0, which in turn can affect ...