We searched the GWAS catalogue for SNPs mapped or attributed to mitotic cohesin ring genes (SMC1A, SMC3, STAG1, STAG2 and RAD21/RAD21-AS), meiosis-specific cohesin ring genes (SMC1B, STAG3, REC8 and ...

The cohesin ring itself acts as a molecular motor to extrude DNA loops, and this activity is thought to underlie its ability to organize the genome (Vian et al., 2018; Mayerova et al., 2020). Cohesin ...

Recently, several studies were carried out to elucidate the role of the cohesin ring in topological entrapment of DNA. Biochemical and crystallographic studies in yeast led to the identification of an ...

A diagram of the protein complex cohesin in its assumed ring-shaped configuration. The scissors represent the action of the enzyme Cut1, which breaks apart the molecule to release DNA.

The cohesin complex mediates DNA-DNA interactions both between (sister chromatid cohesion) and within chromosomes (DNA looping). It has been suggested that intra-chromosome loops are generated by ...

Twenty years ago, the protein complex cohesin was first described by researchers. They found that its shape strikingly corresponds to its function: when a cell divides, the ring-shaped structure ...

The spatial organization, correct expression, repair, and segregation of eukaryotic genomes depend on cohesin, ring‐shaped protein complexes that are thought to function by entrapping DNA.It has been ...

The ring-shaped cohesin traps chromosomes inside its ring and regulates chromosome segregation during mitosis and transcription during interphase. The sister chromatid cohesion 2 protein (Scc2) opens ...