† Division of Chemical Biology and Medicinal Chemistry, University of North Carolina at Chapel Hill, Eshelmann School of Pharmacy, Chapel Hill, North Carolina 27599, United States ‡ Department of ...

1,4-Dihydroxy-2-naphthoyl-coenzyme A (DHNA-CoA) synthase, or MenB, catalyzes an intramolecular Claisen condensation involving two oxyanion intermediates ... loop is folded in interaction with the ...

A reaction mechanism is a sequence of elementary reactions that can explain how an overall chemical reaction proceeds. Gold redox catalysis has remained challenging owing to the high redox ...

Nonetheless, the range of laboratory conditions tested to date is limited and the impact of realistic early Earth conditions on condensation reactions remains unexplored. Here, we investigate the ...

The increased frequency during the high pollen season lends weight to the widely accepted hypothesis that VKC is an immunologically mediated hypersensitivity reaction to environmental antigens.

Conclusion: This study clarifies osimertinib-induced CAR mechanisms involving multi-target interactions and pathway dysregulation, aiding clinical safety and future research. Therefore, this study ...