Vibrio cholerae presents a unique model of bacterial genome organisation through its bipartite genome, comprising two distinct chromosomes that replicate in a carefully orchestrated manner.

The events of chromosome replication and meiosis are obviously critical as well known from classical genetics. Even a mutation at a single base (not even a base pair) can be transmitted to the ...

BrdU-33258 Hoechst analysis of DNA replication in human lymphocytes with supernumerary or structurally abnormal X chromosomes Samuel A. Latt Huntington F. Willard ...

If DNA bridges persist between chromosomes during cell division, chromosomes are abnormally segregated, leading to genetic instability and cancer. Researchers at UNIST and IBS have experimentally ...

In bacteria, DNA replication begins with the assembly of a DNA-protein complex called the orisome (Grimwade and Leonard, 2021). Formation of this complex is a multistep process that starts with ...

Systemic sclerosis (SSc) is a severe autoimmune disease with complex genetic causes. Some genetic contributors have been ...

The last few years have provided us with a new level of understanding of how chromosomes are replicated, segregated and read - and how their 3D organisation influences expression of individual genes ...

Chromosome replication is strictly regulated to ensure successful duplication of the genetic material (Costa and Diffley, 2022; Grimwade and Leonard, 2021; Kasho et al., 2023).In Escherichia coli, the ...

A large trial shows that the vitamin may delay one biological mechanism linked to aging, but don’t rush out to buy ...

Researchers have long advocated for a more systematic approach to environmental health, but funding may not hold.

The team analyzed a large-scale dataset with 928,605 adult participants, including 1,225 adults with sex chromosome aneuploidies (SCAs)—genetic conditions where individuals have an abnormal ...

Genetic study identifies FOXP4 as a key factor in long COVID, emphasizing the importance of diverse population inclusion.