The improper segregation of chromosomes during cell division leads to abnormalities that disrupt the proper functioning of ...

Yet, experimentally induced aneuploidy initially leads to adverse effects and impaired proliferation, suggesting that cancer cells must adapt to aneuploidy. We performed in vitro evolution of cells ...

Since aneuploidy slows down the growth of healthy cells and often leads to cell death, a key question in cancer research is: why and how are cancer cells with this genetic burden able not only to ...

"When a cell is aneuploid, it has an altered set of chromosomes," explains Storchová. A well-known example of aneuploidy is found in people with Down-Syndrome, who have an extra copy of ...

Since aneuploidy slows down the growth of healthy cells and often leads to cell death, a key question in cancer research is: why and how are cancer cells with this genetic burden able not only to ...

DNA damage repair alterations as predictive biomarker for platinum-based chemotherapy in metastatic urothelial cancer.

A Valind, Y Jin, B Baldetorp, D Gisselsson, Whole chromosome gain does not in itself confer cancer-like chromosomal instability. Proc Natl Acad Sci USA 110, 21119–21123 (2013).

Since aneuploidy slows down the growth of healthy cells and often leads to cell death, a key question in cancer research is: why and how are cancer cells with this genetic burden able not only to ...

8, 2025 — Findings from a multi-institutional, international study have significantly advanced the understanding of genetic alterations in the BRCA2 gene, a key player in hereditary cancer ...