Scientists have advanced human-animal chimera research by successfully growing human cells within the organs of mice. This ...

ARV-393 demonstrated significant single-agent activity in models of nodal T-follicular helper cell lymphoma, ...

A new technique that alters protein production in mitochondria could help researchers understand mitochondrial diseases as ...

Mitochondria supply the body with the energy currency adenosine triphosphate (ATP), which drives all bodily activities. For ...

They use a chemically modified small protein fragment known as a chimera. It contains the necessary information, a kind of “zip code”, to enter the mitochondria. Once there, it interferes specifically ...

"The molecular biology capabilities of WIV and the genome assessment are consistent with the hypothesis that SARS-CoV-2 was a ...

On April 27, 2024, near the Sagrada Familia in Barcelona, a touring bus was blocked, sprayed with water pistols, and a banner ...

A new FDA application for vepdegestrant offers hope for advanced breast cancer patients with ESR1 mutations, showcasing promising trial results.

Company to showcase preclinical studies of ARV-393, an investigational oral PROTAC BCL6 degrader, as a single agent in models ...

The unfolded protein response (UPR) is a crucial signaling network that preserves endoplasmic reticulum (ER) homeostasis, impacting both health and disease. When ER stress occurs, often due to an ...

Bridged proteolysis targeting chimera (PROTAC) enables degradation of the cyclin D undruggable protein [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2025; ...

Centre for Targeted Protein Degradation, School of Life Sciences, University of Dundee, 1 James Lindsay Place, Dundee DD1 5JJ, U.K. Centre for Targeted Protein Degradation, School of Life Sciences, ...