In patient-derived and animal tumour models, mubritinib suppressed glioblastoma stem cells and tumour growth by targeting ...

In summary, culturing NSCs under hyperoxia affects their proliferation regarding mitotic activity and cell cycle distribution. Despite severe differences regarding the total number of cells, cell ...

Researchers have found that Artemisia herba-alba, a medicinal herb, contains compounds capable of fighting colorectal cancer.

Cyclin-dependent kinases 4 and 6 (CDK4/6) are crucial cell cycle regulators and have become significant targets in breast cancer therapy. Current CDK4/6 inhibitors, while effective, often come with ...

Biomedical research has long focused on the complexity of cell cycle regulation and the molecular mechanisms underpinning various diseases. Recent advancements in this field have shed light on novel ...

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Association between ctDNA levels, timing of blood collection, and overall survival in metastatic colorectal cancer. This is an ASCO Meeting Abstract from the 2025 ASCO Gastrointestinal Cancers ...

This study provides a valuable new resource to investigate the molecular basis of the particular features characterizing the pipefish embryo. The authors found both unique and shared gene expression ...

ABSTRACT: GSPT2 (G1 to S phase transition protein 2) has emerged as a critical regulator of the cell cycle and has garnered increased attention for its role in tumor biology in recent years. This ...

stabilizer TH-301 in models of pancreatic ductal adenocarcinoma (PDAC). It was seen that treatment with TH-301 led to significant dose-, time- and cell type-dependent decreases in viability.