Cells undergoing ferroptosis secrete Galectin-13, which binds to CD44 and inhibits the plasma membrane localization of SLC7A11 in neighboring cells, thereby accelerating neighboring cell death and ...

为解决免疫疗法（如免疫检查点抑制剂 ICIs）缺乏有效预后生物标志物的问题，研究人员开展了关于癌症干细胞标志物 CD44 在 33 种人类癌症中预后价值及免疫功能的研究。结果发现 CD44 与肿瘤分期、预后及免疫微环境相关，可作为潜在免疫治疗靶点和生物标志物。

Dr. Claire Trivin-Avillach: The diagnostic tests in this case were a serum enzyme-linked immunosorbent assay (ELISA) and indirect immunofluorescence testing for circulating anti-PLA2R antibodies.

Immunofluorescence: The pathognomonic feature is predominant or codominant IgA deposits in the mesangium. These deposits are typically granular and may be accompanied by C3, IgG, and/or IgM.

该纳米凝胶通过CD44靶向递送药物至溶酶体，引发溶酶体膜透化(LMP)和ROS积累，诱导AML细胞分化为粒细胞-单核细胞，同时降低系统毒性，为rrAML提供了化疗-分化联合治疗新策略。 急性髓系白血病(AML)是一种恶性血液肿瘤，传统化疗和造血干细胞移植的疗效在难治 ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Corneal diseases can cause severe visual ...

2025年年初，国家卫生健康委员会发布了《2025年全民健康体重管理行动计划》，明确提出将体重管理作为年度重点健康工作之一，通过政策引导 ...

Department of Clinical Pharmacology, The Second Hospital of Anhui Medical University, Hefei 230601, China Clinical Research Unit, Changhai Hospital, Naval Medical University, Shanghai 200433, China ...

“If you then multiplex, you have to overcome this massive data challenge.” To facilitate the exploration of complex tissues, Vizgen offers a range of VUE multiplex immunofluorescence (mIF) biomarker ...

The demonstration of the hemophilic adhesion molecule CD31's localization to the migrating neutrophil's uropod and required signaling through its ITIM domain are valuable findings. Convincing evidence ...

Alpana Mohta, MD, is a dual board-certified dermatologist, venereologist, and leprologist, with a research focus on immunotherapy for viral diseases and autoimmune disorders. With over 80 publications ...