AIMS This study was undertaken to confirm the distribution and expression of the molecule CD44 on human corneas under normal and pathological conditions. METHODS Fifty eight corneal buttons from adult ...

This important study provides solid evidence to support the anti-tumor potential of citalopram, originally an anti-depression drug, in hepatocellular carcinoma (HCC). In addition to their previous ...

Objective Tumour heterogeneity represents a major obstacle to accurate diagnosis and treatment in gastric adenocarcinoma (GA). Here, we report a systematic transcriptional atlas to delineate molecular ...

This study presents an important application of high-content image-based morphological profiling to quantitatively and systematically characterize induced pluripotent stem cell-derived mixed neural ...

Subsequently, the proteins were isolated and further transferred onto a polyvinylidene fluoride (PVDF) membrane (ThermoFisher, China), blocked with 5% skimmed milk powder, and incubated with primary ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Oncolytic adenoviruses were designed to reach ...

1 University of Oxford Medical School, Level 2 Academic Centre, John Radcliffe Hospital, Oxford, UK Correspondence to Dr Gabriele C DeLuca, Nuffield Department of Clinical Neurosciences Level 1 West ...

Macrophages are crucial immune cells within the tumor microenvironment (TME), involved in regulating tumor proliferation, invasion, metastasis, ECM remodeling, angiogenesis, and immunosuppression.

In this study, we demonstrate the feasibility of generating virtual stains for hematoxylin and eosin (H&E) and a multiplex immunofluorescence (mIF) immuno-oncology panel (DAPI, PanCK, PD-L1, CD3, and ...

Institute of Chemical Biology, Shenzhen Bay Laboratory, Shenzhen 518132, China ...