Hyaluronan can be taken up by cells in a CD44-dependent manner 54. It is not clear which signalling process triggers endocytosis, although an associated receptor tyrosine kinase might be involved ...

CD44 is a glycoprotein found on the surface ... participated in these phenomena by allowing iron to enter cells through endocytosis. Scientists at the Laboratoire Chimie et Biologie du Cancer ...

During the transition to this state, the protein CD44 takes over from transferrin and its TfR1 receptor and ensures the majority of the iron endocytosis. This leads to a significant increase in ...

There is an elevated amounts of iron in persister cancer cells. In these cells, iron is taken up preferentially by CD44-mediated endocytosis, where iron binds to hyaluronic acid and this glycan ...

Researchers investigating the role of the protein CD44 in obesity and metabolic health found that CD44-deficient mice stayed lean even on a high-fat diet, while the control mice developed obesity.

Taking a step in that direction, a team led by researchers at Baylor College of Medicine has discovered that breast cancer cells can shift between two forms of the cell surface molecule CD44 ...

Scientists have implicated an interplay between overexpression of hyaluronan synthase 2 (HAS2) and CD44—the major cell surface receptor for hyaluronan (HA)—in the mechanism that triggers ...

More information: Elizabeth J. Franzmann et al, Salivary CD44 and Total Protein Levels to Detect Risk for Oral and Oropharyngeal Cancer Recurrence, JAMA Otolaryngology–Head & Neck Surgery (2024 ...