铁死亡肿瘤细胞通过分泌 Galectin-13 与邻近肿瘤细胞膜上的 CD44 结合来抑制 SLC7A11 的质膜定位，增强邻近肿瘤细胞铁死亡敏感性，从而引发铁死亡传播。

Researchers investigating the role of the protein CD44 in obesity and metabolic health found that CD44-deficient mice stayed lean even on a high-fat diet, while the control mice developed obesity.

HA-drug couplers are synthesized as prodrugs through the formation of cleavable chemical bonds between a drug and HA, which improve the solubility and pharmacokinetic properties of the drug, as well ...

The pDNA-formed polyplex with a low PEI content (CP(L)) was least cytotoxic and had a transfection efficiency comparable to Lipofectamine/pDNA. The good uptake of CP(L)/pDNA into U87 cells was ...

Thus, CD44 expression in ECs is correlated with angiogenesis ... To inhibit EC movement, CD82 likely enhances CAM endocytosis by changing CAM-membrane microdomain interactions. Without CD82, higher ...

In-depth global and phosphoproteomic analyses of tumor cells deficient with CD81 or CD44 unveils endocytosis-related pathway alterations, leading to further identification of a quality-keeping role of ...

CD44 depletion combined with EGFR inhibitor results in a robust and synergistic GBM ... Here, we report an unexpected finding that the CD44s splice isoform attenuates endocytosis-mediated EGFR ...