DTPs are characterized by high expression of the iron-uptake protein CD44 and the accumulation ... leading to internalization by endocytosis and transport to lysosomes, and an iron-activating ...

Endocytosis is the internalisation of extracellular material. Endocytic pathways include clathrin-dependent endocytosis, caveolae-dependent endocytosis, macropinocytosis and phagocytosis ...

Department of Nutrition, Case Western Reserve University, Cleveland, Ohio 44106, United States Department of Nutrition and Health Sciences, University of Nebraska-Lincoln, Lincoln, Nebraska 68583, ...

本研究针对宫颈癌微环境异质性和免疫逃逸机制不明的问题，通过整合单细胞RNA测序(scRNA-seq)和空间转录组(stRNA-seq)技术，系统揭示了从HPV感染到恶性肿瘤进程中SPP1+巨噬细胞通过SPP1-CD44信号轴塑造免疫抑制微环境的关键作用。研究发现该细胞群在癌组织中显著富 ...

Biomedical Polymers Laboratory, and Jiangsu Key Laboratory of Advanced Functional Polymer Design and Application, College of Chemistry, Chemical Engineering and Materials Science, and State Key ...

本研究针对结直肠癌（CRC）中上皮-间质转化（EMT）驱动肿瘤转移与免疫逃逸的机制不明问题，通过多组学分析与功能实验 ...