Versatile new technology featuring an antibody fused with an antigen, harnesses the power of immunotherapy and vaccines by stimulating dendritic cells through CD40 to deliver a targeted and effective ...

CD44 is a ubiquitous leukocyte adhesion molecule involved in cell-cell interaction, cell adhesion, migration, homing and differentiation. CD44 can mediate the interaction between leukemic stem cells ...

This is an important study that develops a method to fluorescently label peptide MHC complexes on live dendritic cells to enable detection of antigen specific T cells in polyclonal populations. Solid ...

T cells and transform them into potent killer cells (cytotoxic T cells). Thanks to this "armoring function," dendritic cells constitute a ray of hope for personalized immunotherapy. With the ...

Shortcut for dendritic cells Date: May 17, 2021 Source: ETH Zurich Summary: During an inflammatory response, things need to happen quickly: researchers have recently discovered that certain immune ...

Dendritic cells are divided into Type 1 (DC1) and Type 2 (DC2) dendritic cells. Each type fulfills different functions: DC1 provide an immune response to bacteria and viruses, DC2 protect against ...

Importantly, these pDCexos required cDCs to prime CD8 T cells, similarly to cross-presenting pDCs, thus identifying the pDCexo/cDCs pathway as a mechanism for pDCs to achieve cross-priming. Although ...

Here we show that cAMP-PKA-CREB signaling (a pattern recognition receptor [PRR]-independent mechanism) regulates conventional type-2 Dendritic Cells (cDC2s) in mice and reprograms their Th17 ...