Glioblastoma (GBM) is the most aggressive and lethal form of brain cancer, with a median survival of only 15 months despite ...

Members of the CD44 transmembrane protein family have functions in many processes in normal life (for example, in haematopoiesis, the immune system and organogenesis), and in pathological ...

CD44, the major hyaluronan (HA) receptor, makes abundant use of alternative splicing and can be located in glycolipid-enriched microdomains (GEMs). The extracellular and the cytoplasmic domains ...

Taking a step in that direction, a team led by researchers at Baylor College of Medicine has discovered that breast cancer cells can shift between two forms of the cell surface molecule CD44 ...

Scientists have implicated an interplay between overexpression of hyaluronan synthase 2 (HAS2) and CD44—the major cell surface receptor for hyaluronan (HA)—in the mechanism that triggers ...

It acts as a co-receptor for so-called receptor tyrosine kinases, such as MET or VEGFR-2, that depend on CD44 for their activation. These enzymes largely influence the activities of tumor cells.

Researchers investigating the role of the protein CD44 in obesity and metabolic health found that CD44-deficient mice stayed lean even on a high-fat diet, while the control mice developed obesity.

Elevated salivary levels of CD44 and total protein (TP) can identify head and neck cancer patients with an increased risk for cancer recurrence, according to a study published online Aug. 15 in ...

We found that splice isoform switching of the CD44 gene must take place in order for cells to undergo EMT. We also discovered a novel splicing-mediated pathway that drives cancer metastasis. We ...