aDepartments of Surgery, New York University, New York, NY, USA bDepartment of Medicine, New York University, New York, NY, USA ...

The Eph receptors are the largest family of receptor tyrosine kinases. They bind glycosylphosphatidylinositol (GPI)-linked and transmembrane ephrin ligands, generating bidirectional signals at ...

HealthDay News — For patients with diabetes, exposure to glucagon-like peptide-1 receptor agonists (GLP-1 RAs) is associated with an increased risk for incident neovascular age-related macular ...

Vepdegestrant, a PROTAC estrogen receptor (ER) degrader, vs fulvestrant in ER-positive/human epidermal growth factor receptor 2 (HER2)–negative advanced breast cancer: Results of the global, ...

Interestingly, MmMYL3 is not the first myosin protein to be identified as a viral receptor. Previous studies have shown that non-muscle myosin IIA acts as a receptor for herpes simplex virus (Arii et ...

But all opioid receptors are not the same. In the current study, the researchers targeted KOR, a subtype of opioid receptor that when activated can decrease synaptic dopamine levels by decreasing ...

Vepdegestrant is an oral proteolysis-targeting chimera (PROTAC) estrogen receptor (ER) degrader that directly harnesses the ubiquitin–proteasome system.In this phase 3, open-label, randomized ...

PK parameters were similar to these in previous phase I studies in healthy adults. The IGS and levels of proinflammatory cytokines after ex-vivo challenge with a Toll-like receptor 7/8 agonist were ...

Discover how bitter taste receptors in the intestines affect aging. A new study identifies specific receptors linked to metabolic changes, inflammation, and lipid metabolism. Learn how these ...

More information: Farhad Dehkhoda et al, Constitutive ghrelin receptor activity enables reversal of dopamine D2 receptor signaling, Molecular Cell (2025). DOI: 10.1016/j.molcel.2025.05.005 Journal ...

Trial in progress (XALute): Phase 3 study of xaluritamig vs investigator’s choice of cabazitaxel or second androgen receptor directed therapy (ARDT) in post-taxane metastatic castration-resistant ...