A protein called angiopoietin-2 (ANGPT2) can both inhibit and encourage blood vessel changes critical for sepsis, a leading ...

The blood-CSF barrier has been far less studied than the blood-brain barrier. Scientists have detected age-related changes in gene expression in the choroid plexus, and have linked these to increased ...

该化合物为线性多肽，N 端修饰邻氨基苯甲酸（Abz）作为荧光供体，C 端连接 2-(2 - 硝基苯基) 乙二胺（EDDnp）作为淬灭基团，形成内淬灭荧光底物。氨基酸序列包含缬氨酸（Val）、丙氨酸（Ala）、天冬氨酸（Asp）、正缬氨酸（Nva）、精氨酸（Arg）和谷氨酰胺（Gln ...

which recently generated positive phase 2 data in the Tailwind study – along with Boehringer Ingelheim's cathepsin C Inhibitor BI-1291583 (phase 2), Sanofi's anti-IL-33 antibody itepekimab ...

Mechanistically, Mtb Mce3C can bind host cathepsin B (CTSB), a lysosome-derived non-caspase protease that determines cell modalities. This binding inhibits CTSB's protease activity towards BH3 ...

Proteases are enzymes that catalyse hydrolysis of the peptide and isopeptide bonds that join amino acids within proteins (known as proteolysis). Proteases can also remove protein post ...

Notably, microglia spatially associated with amyloid plaques exhibited increased expression of TREM2 and ApoE compared to ...

组织学分析：对术后第 7 天的样本进行免疫组织化学染色，检测组织蛋白酶 K（cathepsin K）和核因子 κB 受体活化因子配体（receptor activator of nuclear factor-kappa B ligand，RANKL）的表达，以评估破骨细胞活性5。 研究结论和讨论部分指出，该研究首次阐明了后路固定在 PS ...

The effect of moisture conditions and canal morphologies on the filling quality of iRoot SP with single-cone technique in root canals: an ex-vivo study ...