ABSTRACT: Cisplatin, a highly efficacious platinum-based anticancer agent, finds widespread application in the management of diverse malignant solid tumors, exhibiting commendable therapeutic outcomes ...

Ventus Therapeutics, a clinical-stage biopharmaceutical company with two novel small-molecule programs entering Phase 2 development for immunological, inflammatory, and neurological disorders, today ...

Z-IETD-AFC 为线性多肽，N 端修饰苄氧羰基（Z），C 端连接 7 - 氨基 - 4 - 三氟甲基香豆素（AFC）荧光基团。氨基酸序列包含异亮氨酸（Ile）、谷氨酸（Glu）、苏氨酸（Thr）和天冬氨酸（Asp），通过肽键连接。苄氧羰基增强多肽的疏水性和细胞膜渗透性，AFC 作为荧光 ...

ChIP-qPCR 实验证实了 ZBTB18 与 Casp3 和 Bid 启动子的结合。活性 caspases 检测实验表明，ZBTB18 BKO GCMP 细胞中活性 caspases 的比例显著增加，且这种增加仅在 Ki67? 细胞中观察到，表明 ZBTB18 通过抑制 Casp3 和 Bid 的表达，促进 MBC 前体的存活。 ZBTB18 对 GC 离开的促进作用 在 ...

这种结构使其能够特异性地与半胱氨酰天冬氨酸特异性蛋白酶（Caspases）结合，并在酶促反应下释放出强烈的荧光信号。 用途： 细胞凋亡研究：Z-VDVAD-AFC是研究细胞凋亡机制的重要工具。在细胞凋亡过程中，Caspases酶类扮演着至关重要的角色。Z-VDVAD-AFC能够特异性 ...

Proteases are enzymes that catalyse hydrolysis of the peptide and isopeptide bonds that join amino acids within proteins (known as proteolysis). Proteases can also remove protein post ...

Autophagy is a cellular degradation pathway for the clearance of damaged or superfluous proteins and organelles. The recycling of these intracellular constituents also serves as an alternative ...

凋亡（Apoptosis）：细胞凋亡又称程序性细胞死亡，是 cfDNA 释放的重要途径。在生理和病理刺激下，细胞内一系列分子事件被触发，其中半胱天冬酶（Caspases）发挥关键作用。Caspases 激活半胱天冬酶激活的脱氧核糖核酸酶（caspase-activated DNase，CAD），CAD 将染色体 DNA ...

This manuscript reports fundamental discoveries on how necrotic cells contribute to organ regeneration through apoptotic signalling to produce cells with non-lethal apoptotic caspase activity that ...

1 Institute of Oncology, Affiliated Tumor Hospital of Nantong University & Nantong Tumor Hospital, Nantong, China 2 Internal Medicine, The Second People’s Hospital of Nantong, Nantong, China ...

This valuable study on strategies used by Pseudomonas to subvert hots immunity identifies a new immune evasion strategy. The study presents solid evidence on the cleavage of VgrG2B by Caspase 11 and ...