For example, researchers will measure cell death to determine a drug’s anticancer effectiveness. Scientists commonly use caspase assays to evaluate apoptosis, evaluating caspase activation—a hallmark ...

癌症作为一种复杂且多样的疾病，给人类健康带来了巨大的威胁。每年，数百万的新发病例使得癌症成为全球第二大死亡原因。尽管科学家们在抗癌药物和治疗方法的研发上取得了显著进展，但癌细胞的不死之术依然是治疗中的巨大挑战。尤其是凋亡机制的逃逸，成为许多癌细胞能够存活并继续增殖的原因。在这一过程中，Caspase-3作为一个关键的凋亡信号转导蛋白，扮演着不可或缺的角色。 2. Caspase-3的激活与癌细胞凋 ...

This focus has evolved to include the investigation of non-apoptotic functions of proteins that have long been considered to have roles in apoptosis, the caspase family of proteases. Our research ...

Discover how stress worsens skin allergies by disrupting immune responses and the role of caspase-1 inhibitors in managing ...

Anti-inflammatory macrophages play crucial roles in various diseases, including cancer, autoimmune disorders, and wound healing.