This platform combines a catalytically inactive Cas13 enzyme (dCas13) that guides the system to specific RNA targets, with a hyperactive variant of the NAT10 enzyme (eNAT10), ... engineering. By ...

RNA gene scissors (CRISPR-Cas13) are gaining significant attention as a next-generation gene therapy with fewer side effects. They can suppress infection by eliminating viral RNA, such as in ...

Traditional biological experimental methods to determine enzyme properties are time-consuming and costly, leading to an increasing interest in computational models for enzyme function prediction.

Subsequently, the CRISPR–Cas13 system has emerged as a potential tool to identify and rectify errors in RNA sequences. CRISPR–Cas13 is a novel technology is specifically engineered for virus ...

Scientists removed unnecessary sections of the Cas13 enzyme, ... by carving out unnecessary bits and then using an artificial intelligence platform called AlphaFold2 to visualize the structure of ...

They discovered that the lentiviral defect in Cas13 systems is caused by previously unknown intrinsic host RNA targeting by Cas13 effectors. This means that it can change endogenous RNAs, such as ...

The small size of the Cas nuclease fused with various effector domains enables a broad range of function. Although there are several ways of reducing the size of the Cas nuclease complex, no efficient ...