Many protein and enzyme drug targets are intractable to the most sophisticated methods in structure-based drug design and discovery (SBDDD) in large part because a high degree of flexibility negates ...

This platform combines a catalytically inactive Cas13 enzyme (dCas13) that guides the system to specific RNA targets, with a hyperactive variant of the NAT10 enzyme (eNAT10), ... engineering. By ...

RNA gene scissors (CRISPR-Cas13) are gaining significant attention as a next-generation gene therapy with fewer side effects. They can suppress infection by eliminating viral RNA, such as in ...

CRISPR-Cas systems have advanced many domains in life sciences, enabling diverse applications in gene editing, diagnostics, and biosensing. Here, we introduce a platform that leverages transcription ...

Malic enzymes are widely distributed in nature and have many biological functions. The crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme in a quaternary complex with NAD+ ...

来自Yu等研究人员开发了基于dCas13-eNAT10融合蛋白的编程化RNA乙酰化系统，首次实现细胞内特定RNA的N4-乙酰胞苷(ac4C)精准修饰。该技术突破传统方法限制，揭示ac4C通过调控转录本亚细胞定位影响基因表达的新机制，为RNA表观遗传学研究提供革命性工具。

Clean energy revolution: Scientists unveil enzyme shaped by nature that could supercharge global biofuel efficiency The discovery came from soil samples hidden beneath sugarcane bagasse, the ...

Bispecific T cell engagers (TcEs) that are able to simultaneously bind to epitopes on cancer cells and T cells are a versatile, highly potent, and economical immunotherapeutic tool ().TcEs are ...

The dimeric structure of the CelOCE enzyme acting on cellulose fibers, represented by the green sticks. Credit: Mario Murakami/CNPEM. The natural protein, known as CelOCE, was developed at the ...

FSP1 is an enzyme that prevents ferroptosis by recycling lipophilic radical-trapping antioxidants, and inhibition of FSP1 sensitizes cancer cells to ferroptosis and suppresses tumor growth.