RNA gene scissors (CRISPR-Cas13) are gaining significant attention as a next-generation gene therapy with fewer side effects. They can suppress infection by eliminating viral RNA, such as in ...

A team led by Professor Won Do Heo from the Department of Biological Sciences, KAIST, has developed a pioneering technology that selectively ...

Malic enzymes are widely distributed in nature and have many biological functions. The crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme in a quaternary complex with NAD+ ...

The Colts have announced a new ownership structure in the wake of the death of team owner Jim Irsay last month. Irsay’s three daughters were all serving as vice-chairs of the team before their father ...

来自Yu等研究人员开发了基于dCas13-eNAT10融合蛋白的编程化RNA乙酰化系统，首次实现细胞内特定RNA的N4-乙酰胞苷(ac4C)精准修饰。该技术突破传统方法限制，揭示ac4C通过调控转录本亚细胞定位影响基因表达的新机制，为RNA表观遗传学研究提供革命性工具。

Over 200 patients were dosed, and 365 enrolled in the Nex-Z MAGNITUDE trial, aiming for 765 by early 2027. Intellia plans BLA filing for NTLA-2002 in HAE by late 2026, with a U.S. launch targeted ...

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