An international team of researchers has uncovered a groundbreaking discovery in the fight against heart disease. They found ...

Effects of VASH1 Knockdown and TTL-E331Q Overexpression on Myocyte Contractility The effect of SVBP depletion was examined in cardiomyocytes from a separate subset of 3 failing hearts (2 HFrEF, 1 ...

The researchers believe that activation of Caren in cardiomyocytes could lead to the development of new heart failure therapies. Heart failure is when reduced pumping function (contraction and ...

Applying increasing pacing frequencies resulted in decreasing contraction amplitudes without positive staircase effect. Gene expression analysis of selected cytoskeleton and myofibrillar proteins ...

Contraction of cellular monolayers is recorded with high resolution in 96 wells ... users by providing both the device through Nanion as well as a screening service through innoVitro. "Human ...

More information: Paula Ortiz-Sánchez et al, Loss of SRSF3 in Cardiomyocytes Leads to Decapping of Contraction-Related mRNAs and Severe Systolic Dysfunction, Circulation Research (2019).

Induced loss of SRSF3 in adult cardiomyocytes results in widespread changes in alternative splicing and decapping of mRNAs encoding contraction proteins and its subsequent degradation, leading to ...

We identified Erb-b2 receptor tyrosine kinase 2-mediated relocalization of N-cadherin (Cdh2) as a mechanism underlying the formation of cell–cell junctions between trabecular and compact layer ...

The main factor preventing the full realization of this potential is the limited maturity of iPSC-CMs, which display a number of substantial differences in comparison to adult cardiomyocytes.