More information: Till Friedmann et al, Catalytic Enantioselective Synthesis of 1,4-(Hetero) Dicarbonyl Compounds through α-Carbonyl Umpolung, Journal of the American Chemical Society (2024). DOI ...

Researchers at Leipzig University have developed a new process for reversing the polarity of chemical compounds, also known as umpolung, for the precise synthesis of pharmaceuticals. This ...

The polarity of an acid is higher because of the hydrogen bond and the carbonyl in the same compound, like a double dose of polarity. When oxygen and hydrogen covalently bond, the bond is very polar.

Every chemical group of a given molecule is characterized by a pattern of electrostatic polarization that dictates the group's reactivity towards other molecules. The polarization of carbonyl (C=O ...

In that experiment, direct current yielded a “sluggish reaction,” whereas rapidly alternating polarity gave total reduction of one of phthalimide’s carbonyl groups under otherwise identical ...

Switching DNA and RNA on and off Date: August 21, 2018 Source: Springer Summary: DNA and RNA are naturally polarized molecules. Scientists believe that these molecules have an in-built polarity ...

01/21/2025 09:26 New process for polarity inversion of chemical compounds for precise drug synthesis Susann Sika Stabsstelle Universitätskommunikation / Medienredaktion Universität Leipzig ...