Our results reveal that PMCA4 regulates the development of cardiac hypertrophy and provide proof of principle for a therapeutic approach to treat this condition. Calcium is an important signal ...

The discovery by a team at the Victor Chang Cardiac Research Institute in Perth, Australia, showed that the molecule Piezo1 initiates the cardiomyocyte ... distinct calcium-dependent signaling ...

dysregulation of calcium-handling proteins, metabolic alterations, cardiomyocyte hypertrophy and cell death. Fibrosis and inflammation are key factors in the progression of this pathological ...

but preliminary research conducted by two separate groups had previously hinted that regulating the calcium pathway might also allow for better healing and cardiomyocyte proliferation in patients ...

dysregulation of calcium-handling proteins, metabolic alterations, cardiomyocyte hypertrophy and cell death. Fibrosis and inflammation are key factors in the progression of this pathological ...

Published in npj Regenerative Medicine, the study reveals a novel approach to promoting cardiomyocyte proliferation ...

Inhibiting the activity of a specific calcium-regulating membrane protein may prevent the thickening of heart muscle tissues, a disorder known as cardiac hypertrophy, a new study finds 1. This insight ...

The discovery of a novel approach to promote cardiomyocyte proliferation ... research highlights the importance of targeting calcium signaling pathways to unlock the regenerative potential of ...

In this study, we show that pharmacological protein kinase C (PKC) activation induces cardiomyocyte hypertrophy via activation of novel PKC isoforms. Both neonatal rat ventricular cardiomyocytes and ...

HNP-1 levels were measured in patients with hypertension and treated HLVH rat and H9c2 cell hypertrophy models with HNP-1. Cardiomyocyte hypertrophy indexes (i.e., single-cell surface area ...

dysregulation of calcium-handling proteins, metabolic alterations, cardiomyocyte hypertrophy and cell death. Fibrosis and inflammation are key factors in the progression of this pathological ...