One of the crucial precursor courses of heart failure (HF) is maladaptive myocardial hypertrophy, which results in subsequent myocyte fibrosis, chronic heart dysfunction, and even sudden death. 1 ...

PD98059 treatment decreased phosphorylation of ERK1/2 that was increased by BMP4. These results suggest that BMP4 induces cardiomyocyte hypertrophy through the activation of ERK1/2 cell signaling ...

Plasma membrane calcium ATPase 4 (PMCA4) is a ubiquitously expressed Ca 2+ pump that is important in mediating molecular signaling in the heart. Here we show a novel role of PMCA4 in cardiac ...

To elucidate the effect of Fibin on cardiomyocyte hypertrophy we investigated the influence of altered ... It has been shown earlier that these two signalling pathways interact, because RhoA itself is ...

whether it regulate the Pink1-Parkin pathway and involve in cardiac hypertrophy remains poorly understood. In this study, we found that Samm50 was downregulated in the cardiac hypertrophy model.

MR is associated with activation of the mammalian target of rapamycin pathway, and mammalian target of rapamycin inhibition prevents cardiomyocyte hypertrophy and preserved left ventricular systolic ...

Here, we investigated the requirement of apoptotic caspase pathways in mediating cardiomyocyte hypertrophy. Cardiomyocytes treated with hypertrophy agonists displayed rapid and transient activation of ...

19 For plasmid–DNA transfection, the calcium phosphate method was used as described ... Taken together, these data support the overall conclusion that estrogen replacement limits LV and cardiomyocyte ...