Our results reveal that PMCA4 regulates the development of cardiac hypertrophy and provide proof of principle for a therapeutic approach to treat this condition. Calcium is an important signal ...

The discovery by a team at the Victor Chang Cardiac Research Institute in Perth, Australia, showed that the molecule Piezo1 initiates the cardiomyocyte hypertrophic ... stimuli were thought to ...

dysregulation of calcium-handling proteins, metabolic alterations, cardiomyocyte hypertrophy and cell death. Fibrosis and inflammation are key factors in the progression of this pathological ...

Inhibiting the activity of a specific calcium-regulating membrane protein may prevent the thickening of heart muscle tissues, a disorder known as cardiac hypertrophy, a new study finds 1. This insight ...

Published in npj Regenerative Medicine, the study reveals a novel approach to promoting cardiomyocyte proliferation ... importance of targeting calcium signaling pathways to unlock the ...

Although cardiomyocyte hypertrophy is widely studied, many of the studies rely on rodent cardiomyocytes or animal models. Since not all human hypertrophic signalling pathways exist in rodents and to ...

Another study revealed that insulin can activate the SPEG-SERCA2a pathway through the protein kinase B (PKB) in the heat, which in turn regulates cardiomyocyte calcium homeostasis. However ...

Targeted genomic approaches (such as gene knockout/knockdown) can then be carried out in an iPSC-derived cardiomyocyte model of hypertrophy to better define the roles of individual factors in cardiac ...

In this study, we show that pharmacological protein kinase C (PKC) activation induces cardiomyocyte hypertrophy via activation of novel PKC isoforms. Both neonatal rat ventricular cardiomyocytes and ...

HNP-1 levels were measured in patients with hypertension and treated HLVH rat and H9c2 cell hypertrophy models with HNP-1. Cardiomyocyte hypertrophy indexes (i.e., single-cell surface area ...