In the most common type of CAH, called 21-hydroxylase deficiency, the adrenal glands also might not make aldosterone. As the adrenal glands work harder to try to make more cortisol, they produce too ...

This guideline focusses solely on CAH caused by 21-hydroxylase deficiency. It is written by the US Endocrine Society (2018) and cosponsored by several other organisations, including the European ...

Male and female subjects 18 to 55 years old who had a documented historical diagnosis of classic CAH due to 21-hydroxylase deficiency based on genetic testing and/or elevated blood test result may be ...

SAN DIEGO - Neurocrine Biosciences, Inc. (NASDAQ:NBIX) has sponsored a supplement in The Journal of Clinical Endocrinology & Metabolism (JCEM) focusing on classic congenital adrenal hyperplasia (CAH), ...

The diagnosis of CAH secondary to 21-hydroxylase deficiency with mutation in CYP21A2 was confirmed by genetic studies. He was discharged home with hydrocortisone, fludrocortisone and sodium chloride.

and pharmacokinetics of atumelnant when administered for 12 weeks in people with CAH caused by 21-hydroxylase deficiency. The study enrolled 28 patients across 3 dose cohorts with classic CAH on a ...

Approximately 95% of CAH cases are caused by variants of the CYP21A2 gene that leads to deficiency of the enzyme 21-hydroxylase (21-OH). Severe deficiency of this enzyme leads to an inability of the ...

The adrenal glands need 21-hydroxylase to make proper amounts of hormones. This type of CAH is sometimes referred to as 21-hydroxylase deficiency. In CAH due to 21-hydroxylase deficiency, the adrenal ...

Male and female subjects who are 18 to 55 years old and had a documented historical diagnosis of classic CAH due to 21-hydroxylase deficiency based on genetic testing may be eligible for this study.

The most common form of CAH is caused by a deficiency in the enzyme 21-hydroxylase, which is crucial for the production of cortisol and aldosterone. This condition can result in serious health ...