The FDA has approved Journavx 50 mg oral tablets for the treatment of moderate to severe acute pain in adults, according to a ...

The drug is cleared by cytochrome P450 (CYP)3A4 metabolism ... Blood levels of eplerenone are increased by inhibitors of CYP3A4, such as ketoconazole and saquinavir. About 50% is bound by plasma ...

Opioid analgesic risk evaluation and mitigation strategy (REMS); Cytochrome P450 3A4 interaction. Assess the potential need for access to naloxone when initiating and renewing therapy. Consider ...

5-hydroxyomeprazole is then transformed into 5-hydroxyomeprazole sulfone by CYP3A4. Omeprazole is metabolized ... could be a more practical. The CYP isoenzymes participating in the metabolism ...

Concomitant use or discontinuation of CYP3A4 inhibitors or inducers ... use with benzodiazepines or other CNS depressants; Cytochrome P450 3A4 interaction. Abuse potential (monitor).