May be antagonized by CYP2B6 inducers (eg, ritonavir, lopinavir, efavirenz, carbamazepine, phenobarbital, phenytoin); may need bupropion dose increase. May potentiate drugs metabolized by CYP2D6 ...

Inducers of CYP450 generally enhance the activity ... are mainly limited to those that are metabolized by CYP3A and CYP2B6. The drugs that can induce CYP3A and CYP2B6 that are likely to interact ...

One such human enzyme, CYP2B6, disables more than a dozen herbicides, pesticides, and industrial chemicals. For some of these compounds, CYP2B6 works better than natural rice enzymes do.