One key area of research has been the role of the cytochrome P4502B6 (CYP2B6) gene, which is crucial for the metabolism of methadone. Variants in this gene can lead to significant differences in ...

The TP53 gene is a gene that is mutated in many cancers. It is the most common gene mutation found in cancer cells. A tumor-suppressor gene, TP53 codes for a protein that inhibits the development and ...

Gene expression is the generation of a functional gene product from the information encoded by a gene, through the processes of transcription and translation. Gene products are often proteins ...

Each gene tells a cell to make a specific molecule, but this isn't performed by the DNA itself. Instead, the information is relayed to cellular machinery by a molecule called messenger RNA.

Jan. 28, 2025 — A team of researchers has developed a novel method to enhance the precision of cancer treatment using gold nanoparticles tagged with DNA ...

This Research Topic seeks to provide new insights, highlight recent advancements, explore current challenges, and discuss future opportunities in the dynamic field of Pharmacogenetics and ...

Pharmacogenomics. 2012;13(2):223-231.

We aim to investigate the dysregulated signaling pathways associated with cardiotoxicity induced by these compounds. Based on our sequencing results, we observed consistent patterns of gene expression ...

New work by Columbia researchers has turned a textbook principle of genetics on its head and revealed why some people who carry disease-causing genes experience no symptoms. Every biology student ...

– FDA Accepted Agios’ Supplemental New Drug Application for PYRUKYND ® (mitapivat) in Adult Patients with Non-Transfusion-Dependent and Transfusion-Dependent Alpha- or Beta-Thalassemia; PDUFA Goal ...

Some genes are beneficial and enhance longevity. For example, the gene that helps a person metabolize cholesterol would reduce a person's risk of heart disease. Some gene mutations are inherited.