Background Cyclophosphamide, an immunosuppressant in patients with lupus nephritis, aims to prevent recurrence and is a steroid-sparing agent. The clinical response (efficacy and toxicity) of lupus ...

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为解决 cyp2b6 和 cyp2c8 相关数据少、预测难的问题，研究人员利用深度学习开展研究。结果显示，多任务学习结合数据插补模型效果显著，这为药物安全性评估提供了有力支持。 在药物研发的神秘世界里，细胞色素 p450（cyp ）超家族扮演着 ...

Effect of TEPYLUTE on Cytochrome CYP2B6 Substrates: In vitro studies suggest that thiotepa inhibits CYP2B6. Thiotepa may increase the exposure of drugs that are substrates of CYP2B6 in patients; ...

Effect of Cytochrome CYP3A Inhibitors and Inducers: In vitro studies suggest that thiotepa is metabolized by CYP3A4 and CYP2B6 to its active metabolite triethylene phosphoramide (TEPA). Avoid ...

Background Amlodipine inhibits cytochrome P450 (CYP) enzyme and has the potential to reduce clopidogrel bioactivation in vivo. Reports in previous retrospective studies described greater platelet ...

Objective: Cyclophosphamide is a conventional pro-drug used in Multiple Myeloma (MM) and other malignancies. The highly polymorphic CYP2B6 is suggested as a major contributor in cyclophosphamide ...

Purpose: To investigate the effects of hepatic enzyme activity variations and CYP2B6 gene polymorphisms on the in vivo and in vitro metabolism of efavirenz. Main methods: In vitro enzyme systems using ...

But CYP2B6*6 is vital in determining Artemisinin pharmacokinetics hence treatment outcome. Interindividual variability may mediate variable responses to artemisinin therapy among malaria ...

Polymorphisms in CYP2B6*6, predominantly CYP2B6: 516GT, are associated with pharmacokinetic changes with important clinical repercussions for some substrates. This variant has often been associated ...