在药物研发中，细胞色素 P450（CYP）介导的药物相互作用至关重要。为解决 CYP2B6 和 CYP2C8 相关数据少、预测难的问题，研究人员利用深度学习开展研究。结果显示，多任务学习结合数据插补模型效果显著，这为药物安全性评估提供了有力支持。 在药物研发的神秘 ...

通过分析HIV、疟疾和结核病等关键疾病的基因-药物相互作用案例（如HLA-B*5701与阿巴卡韦、CYP2B6 * 6与依非韦伦），研究提出通过成本效益分析、基础设施建设和政策协同推动PGx落地，为非洲精准医疗提供循证依据。 在非洲，药物不良反应和治疗失败是医疗系统的 ...

Principal catalysts of the hepatic ifosfamide 4-hydroxylation are CYP3A4 and CYP2C9 enzymes, while CYP3A4 and CYP2B6 have demonstrated the major isoforms in the hepatic N-dechloroethylation ...

We have developed a luminogenic CYP2B6 assay for biochemical CYP2B6 inhibition and for cell-based CYP2B6 induction studies. Here we present the CYP2B6 luminogenic assay characterization and ...

Concomitant phenothiazines, other tranquilizers: reduce dose by 25–50%. Concomitant use or discontinuation of CYP2B6/CYP3A4 inhibitors or inducers: monitor closely and consider dose adjustments ...