来自国内的研究人员针对牙周炎中牙周膜干细胞(PDLSCs)成骨分化障碍的机制展开研究，发现牙龈卟啉单胞菌(P. gingivalis)通过铁过载介导的DNA氧化损伤下调CTCF表达，而铁螯合剂DFO和重组CTCF蛋白可逆转这一过程。该研究为靶向CTCF-铁代谢轴治疗牙周骨缺损提供了新思路。

Although CTCF expression is not significantly altered in transverse aortic constriction, the depletion of CTCF leads to dire cardiac pathology, 1,2 in agreement with its necessary role in ...

It features several CTCF binding sites , and in MCF-7 cells, we demonstrate that it blocks the propagation of the 4C signal between the two flanking TADSs . Future studies will help elucidate how ...

We aimed to clarify the role of G4s in CTCF positioning. Mol. modeling data suggested direct interactions, so we performed in vitro binding assays with quadruplex-forming sequences from CGIs in the ...

We thank Y. Zhai and Y. Zhang for technical assistance and Sangon Biotech Corporation (Shanghai, China) for help with sequencing. This work was supported by the National Key Research and Developmental ...