CRISPR is not only enabling more complex combinations of traits to be tested in mouse models but also opening up new possibilities for modeling disease in rats. Even so, the technology remains a ...

Now, however, scientists have developed a series of sophisticated mouse models using CRISPR ('clustered regularly interspaced short palindromic repeats') technology that allows them to ...

While amyloid-beta has been a central focus in drug development, increasing evidence points to tau pathology as a more accurate predictor of disease progression. This is where the work of Dr. Naoto ...

This study, published in Neurobiology of Disease, describes the first avatar model for the disease ... drugs can reach the brain of the mutant mouse and improve all these alterations", explains ...

Blood 2021; 137(12): 1628–1640), St. Jude Children’s Research Hospital scientists generated a novel CRISPR-induced mouse model of acute erythroid leukemia. The model was developed using ...

Duke University Medical Center-led research has identified a human-specific DNA enhancer that regulates neural progenitor ...

A team of medical researchers from the University of Texas Southwestern Medical Center, Case Western Reserve University School of Medicine and ReCode Therapeutics has developed a way to send gene ...

A big breakthrough is being hailed in the world of gene editing, with the first custom-designed treatment using CRISPR ...

In new mouse models of the disease ... To fix the dysferlin mutation, Escobar uses CRISPR-Cas9, which is often described as "gene-editing scissors" and for which a Nobel Prize was awarded in ...

CRISPR gene editing has revolutionized genetics ... DMD-targeting experiments in a humanized mouse model demonstrated 10–40% editing in quadriceps, calf, and heart tissues.

Now, however, Yale scientists have developed a series of sophisticated mouse models using CRISPR (“clustered regularly interspaced short palindromic repeats”) technology that allows them to ...