CRISPR-Cas12a, one of the DNA-cutting proteins revolutionizing biology today, has an unexpected side effect that makes it an ideal enzyme for simple, rapid and accurate disease diagnostics. Cas12a ...

CRISPR-Cas12a DNA cleavage patterns, as evaluated in a quantitative kinetics study, suggest that the less frequently used Cas12a enzyme has greater target specificity than the more popular Cas9 ...

An appealing alternative to the Streptococcus pyogenes CRISPR nuclease SpyCas9, are Type V CRISPR Cas12a nucleases, commonly isolated from Acidaminococcus (Asp) and Lachnospiraceae (Lba). These ...

His new work contributes six novel variants of CRISPR-Cas12a in plants, testing first in rice as a major global crop. In addition to broadening possible gene editing targets, these tools can edit ...

CRISPR-Cas12a was the first system after CRISPR-Cas9 to be used for gene editing in the lab. A recent study on Cas12a’s cousin Cas12b demonstrated that this variant could edit the human genome ...

Is CRISPR-Cas12a feasible for the detection of SARS-CoV-2? To determine the feasibility of CRISPR-Cas12a-based detection, cRNA was designed to correspond to part of the nucleocapsid (N) gene.

The researchers were also able to identify genes that led to accelerated lymphoma growth in the pre-clinical model by using unique Cas12a-compatible mouse whole-genome CRISPR "libraries".

CRISPR-Cas12a, one of the DNA-cutting proteins revolutionizing biology today, has an unexpected side effect that makes it an ideal enzyme for simple, rapid and accurate disease diagnostics. Cas12a ...