First, there is decreased CREB activation in post-mortem hippocampal tissue from AD patients (Yamamoto-Sasaki et al, 1999; Satoh et al, 2009). Second, analysis of an ‘AD transcriptome ...

However, the exact correlation between hippocampal CREB phosphorylation and memory improvement induced by Rolipram has not yet been determined in a CREB-dependent type of hippocampal-related ...

Fos, are integral to the brain's response to stimuli. Initially identified as a proto-oncogene, c-Fos is essential for neural ...

In our own investigations of CREB, we homed in on its function within specific brain regions we knew were involved with memory: the amygdala and the hippocampus. The latter stores an internal map ...

The work, she said, suggests that cells expressing CREB are preferentially incorporated into memory traces in the brain (see Han et al., 2009). How does this matter to Alzheimer disease? Josselyn has ...

Furthermore, the researchers found that a protein called Creb became more activated in the brain region known as the hippocampus, and that this increased activity was associated with the anatomical ...

Caccamo and colleagues injected a lentivirus carrying the CBP gene into the lateral ventricle, from where the virus diffused into the hippocampus. In this manner, overexpression of CBP restored CREB ...

Therefore, how an antidepressant works on the biochemistry and behavior in a mouse in which the CREB protein is deleted only in the hippocampus versus a wild type mouse in which CREM is ...

In the hippocampus, which is the learning and memory center of the mammalian brain, treatment with ramelteon/AMK significantly increased the phosphorylation of both ERK and CREB. However ...

Researchers have investigated how neuronal activity influences cAMP response element binding protein (CREB) dynamics. Osaka University-led researchers investigate how neuronal activity influences ...

Researchers have found that the hippocampus of poor learners has less CREB (a protein involved in memory and learning) and more alpha5 subunit of GABAA receptor or GABRA5 (a protein that generates ...

Erasing them was just a step towards doing that. Han’s found that a protein called CREB is a molecular beacon that singles out neurons involved in remembering fearful experiences. When a rat ...