Figure 1: Homologues of cellular cyclins encoded by the viruses KSHV (KS) and γMH68 (γ68) bind to one or more cellular cyclin-dependent kinases (CDKs) and phosphorylate an increased number of ...

Why do medications that are supposed to help patients with chronic inflammatory diseases sometimes lead to blood clots?

Colchicine, doxorubicin (adriamycin), mitoxantrone, and verapamil were purchased from Sigma Aldrich Trading Co. (Shanghai, China). All of the drugs were dissolved in 100% DMSO to produce a 10 mM stock ...

In atherosclerosis, the vascular smooth muscle cell (VSMC) contributes to vessel wall inflammation and lipoprotein retention, as well as to the formation of the fibrous cap that provides stability ...

With stage IV, the breast cancer has spread to other parts of your body. Often the bones, brain, lungs, or liver are affected. Because multiple areas may be involved, focused treatments like ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Glioblastomas (GBM) are treated with high ...

为克服抗骨质疏松药物局限，研究人员探究新骨形成因子，发现 VGF 和 AQEE30 可促进成骨，意义重大。 骨质疏松，作为一种常见的代谢性骨病，如同隐藏在身体里的 “沉默杀手”，悄无声息地侵蚀着人们的骨骼健康。它以低骨量和微结构改变为特征，大大增加了 ...

After hours: March 14 at 5:23:50 p.m. EDT Loading Chart for RLAY ...

蛋白激酶 A（PKA）、蛋白激酶 C（PKC）家族以及 p70 核糖体 S6 激酶（RPS6K）在 LBBC 中被强烈激活，而细胞周期蛋白依赖性激酶（CDKs）则受到显著抑制。磷脂酰肌醇 3 - 激酶 - 哺乳动物雷帕霉素靶蛋白复合物 1（PI3K-mTORC）和 Hippo 信号通路在癌症中特异性激活也备受 ...