In a recent study, Dr. Jennifer Lund, a professor in the Vaccine and Infectious Disease Division, and her team demonstrated that bystander-activation of memory CD8 T cells during Herpes Virus 2 (HSV-2 ...

Antiretroviral therapy (ART) initiated in the acute phase of HIV infection (AHI) results in a smaller viral reservoir. However, the impact of early HIV-specific T-cell responses on long-term reservoir ...

Capstan Therapeutics scientists demonstrate that lipid nanoparticles can engineer CAR T cells within the body without ...

In a human-mouse xenogeneic GvHD (xGvHD) model, ALTB-268 significantly improved survival, reduced disease severity score and body weight loss, and decreased human CD4+ and CD8+ T cells, while ...

Findings indicate that frequent COVID-19 booster shots do not weaken T-cell responses, alleviating concerns for vulnerable ...

In response, the T cells activate and make copies of themselves ... A variant form of LGL leukemia involves a specific T cell called CD8+. CD8+ T cells are T cells that carry the co-receptor ...

If antigen binding does not impact T-cell receptor structure, how does it trigger T-cell activation? The research team suggest that the CD8 receptor may also play a crucial role, by phosphorylating ...

Cytotoxic or CD8 + T-cells, known for their ability to kill infected and cancer cells, require activation and differentiation within specialized niches of the tumor microenvironment to effectively ...

Initial data demonstrate a highly differentiated clinical pharmacodynamic profile with unprecedented levels of selective CD8+ T cell activation as well as initial evidence of anti-tumor effect ...

They recognize pathogens and secrete cytokines that activate other immune cells, including CD8+ T cells. However, they have no direct involvement in attacking and neutralizing pathogens.

While Halters is still piecing together the mechanisms underlying these effects, he thinks something about the activation of the brain endothelium in ApoE4 carriers seems to play a hand in easing the ...