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24 天
促进多西他赛耐药新机制!上海交大发文:癌症基因治疗新靶点
【导读】大多数前列腺癌患者不可避免地会发展为去势抵抗性前列腺癌(CRPC),此时多西他赛等化疗药物成为一线治疗手段。然而,在最初一段治疗有效期后,通常会出现化疗耐药性。 1月14日,上海交通大学研究团队在期刊《Journal of Experimental & Clinical Cancer ...
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24 天
促进多西他赛耐药新机制!上海交大发文:癌症基因治疗新靶点
MeRIP 实验和 SELECT 实验揭示,METTL13 通过 m6A 甲基化转录控制 CD44 的 mRNA 降解。此外,这一过程激活了 pSTAT3/PI3K-AKT 信号通路。研究还表明,降低 AGD1 ...
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