CD4 T helper cells are a type of white blood cell called a lymphocyte that serves an important role in your immune system. These cells help defend the body against infection by directing other "killer ...

Introduction: During T cell development, heterogeneous nuclear ribonucleoprotein (hnRNP) L is known to regulate CD4 T helper subset differentiation ... For intracellular staining of transcription ...

The lower respiratory tract is covered with a 75 m 2 monolayer of epithelial cells that separate the outside world from the underlying vasculature and protect the interstitial tissue.

Subcutaneous LCMV infection induces T H 1 cell polarization while largely compromising T FH cell differentiation and humoral immunity. T-cell-derived IFN-γ produced in the first days upon infection ...

T cells are a type of white blood cell that is central to your immune defense. Four types that serve different functions include: CD4 and CD8 are two different types of glycoprotein found on the ...

SARS-CoV-2 spike (S) protein-specific T-cell responses were measured by intracellular cytokine staining and polyfunctionality analyses. Conclusion: Overall, a three-dose mRNA-1273 primary series ...

Tet1/3 supported chromatin accessibility at TCR-responsive regulatory elements enriched in motifs belonging to bZIP, ETS, RUNT, and NFAT transcription factor families, which are known transcriptional ...

ncl.ac.uk Objectives A previously identified signal transduction and activator of transcription-3 (STAT3) target-enriched gene signature in circulating CD4+ T cells of patients with early rheumatoid ...

慢性肝病进展至肝纤维化缺乏有效治疗手段。研究人员开展了 T 细胞自噬在肝纤维化中作用的研究，发现患者 CD4 T 细胞自噬缺陷，且自噬缺陷的 CD4 T 细胞通过 IL-17A 和 GM-CSF 加重肝纤维化，激活自噬可缓解，为肝纤维化治疗提供新方向。 在医学领域，慢性肝病 ...

Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, United States Department of Pathology and Laboratory Medicine, Brown ...

本期推荐：研究团队通过小鼠模型和人胎儿脑组织实验，揭示CD4 + T细胞通过分泌IFN-γ抑制神经元中巨细胞病毒（CMV）的复制和再激活，为先天性CMV感染导致的神经发育障碍提供治疗新靶点，成果发表于《Journal of Neuroinflammation》。 在人类疱疹病毒家族中 ...