Computational analysis of the variations in the HIV-1 genome sequence that correlate with preferential binding to the CCR5 (C-C-motif receptor 5) or CXCR4 (C-X-C motif receptor 4) coreceptors in ...

These sites bind to coreceptor CCR5 or CXCR4 on the membrane of the host cell (center panel), an event that initiates steps that culminate in the fusion of the HIV envelope with the host cell ...

The use of combination antiretroviral therapy results in a substantial reduction in viremia, a rebound of CD4 + T cells and increased survival for HIV-infected ... with either CCR5- or CXCR4 ...

The chemokine receptors CCR5 and CXCR4 are the two major coreceptors for HIV entry. Numerous efforts have been made to develop a new class of anti-HIV agents that target these coreceptors as an ...

For the first time, the treatments would be aimed not at the virus itself, but at a portal through which HIV enters white blood cells and attacks the immune system. Scientists in 1996 identified ...