Activation, proliferation and differentiation of CD8+ cytotoxic T cells must be carefully regulated. New evidence suggests that antigen and costimulation may be enough to trigger the program.

Objective Checkpoint immunotherapy unleashes T-cell control of tumours but is suppressed by immunosuppressive myeloid cells. The transmembrane protein MS4A4A is selectively highly expressed in ...

研究人员针对脾脏成纤维网状细胞（frcs）在抗病毒免疫应答中的作用机制这一关键科学问题，通过构建ccl19-dtr小鼠模型，结合单细胞测序和时空动态分析技术，揭示了frcs通过协调病毒复制、调控炎症微环境促进树突状细胞（dc）成熟，进而优化cd8+ t细胞活化和记忆形成。

编辑推荐： 研究人员通过条形码谱系追踪和单细胞转录组分析，揭示了流感病毒感染后引流淋巴结(dlns)中cd69+cd103+病毒特异性cd8+ t细胞与肺trm细胞的动态关联，发现ccr5-ccl5轴介导的肺-dln逆向迁移对维持呼吸道记忆t细胞库至关重要，为优化局部抗感染免疫应答提供新靶点。

In T cells, there is partial overlap in differentially expressed genes between CPAM and healthy samples. Genes such as CCL5, NKG7, ... KM, Dowling, MR, Shembrey, C, Noori, T, Kearney, CJ, et al. NKG7 ...

Secondary endpoints were response rate (RECIST 1.1), recurrence free survival (RFS), and safety. CD8-PET imaging was done pre-ICB and pre-surgery, using 89 Zr-radiolabeled crefmirlimab to evaluate ...

Multiomic evaluation of TEV-56278, a PD-1-targeted attenuated IL-2 molecule, in a human ex vivo tumor model and association with immune activation with enhanced effector CD8 T cell selectivity.. JCO ...

Marvel and DC's next comic crossover revealed: Deadpool and Batman — See a first look (exclusive) “The Big Two” finally unveil their long-kept secret and tease another crossover event in 2026.

Marvel and DC are finally joining forces on their first crossover comic in 22 years. Find out what to expect when Batman and Deadpool cross paths.