研究人员针对脾脏成纤维网状细胞（frcs）在抗病毒免疫应答中的作用机制这一关键科学问题，通过构建ccl19-dtr小鼠模型，结合单细胞测序和时空动态分析技术，揭示了frcs通过协调病毒复制、调控炎症微环境促进树突状细胞（dc）成熟，进而优化cd8+ t细胞活化和记忆形成。

编辑推荐： 研究人员通过条形码谱系追踪和单细胞转录组分析，揭示了流感病毒感染后引流淋巴结(dlns)中cd69+cd103+病毒特异性cd8+ t细胞与肺trm细胞的动态关联，发现ccr5-ccl5轴介导的肺-dln逆向迁移对维持呼吸道记忆t细胞库至关重要，为优化局部抗感染免疫应答提供新靶点。

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