研究人员发现趋化因子CCL5和CXCL9与实体瘤中的CD8+ T细胞浸润有关，并且具有CCL5和CXCL9共表达的肿瘤患者具有更长的存活期，以及对免疫检查点阻断治疗更敏感。 近期的Cancer Cell发表了一篇题为“Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and ...

这项研究发表在最新一期的《Cancer Cell》杂志上 ... 的团队发现了两种趋化因子，CCL5和CXCL9，它们与实体肿瘤的CD8+ T细胞浸润一致相关。

称之为“组合基因（combinatorial genes）”，例如Ccl5，Tnf ... 作者想在人群中证实T cell help优化CD8+T细胞的抗感染能力。事实上，已有线索表明IFNα ...

中CD69+CD103+病毒特异性CD8+ T细胞与肺TRM细胞的动态关联，发现CCR5-CCL5轴介导的肺-dLN逆向迁移对维持呼吸道记忆T细胞库至关重要，为优化局部抗感染免疫应答提供新靶点。 在抵御病原体入侵屏障组织的过程中，组织驻留记忆T细胞(Tissue-resident memory T cells, T RM ...

In the current study, Coukos and his team identified two chemokines, CCL5 and CXCL9, that are consistently associated with CD8+ T cell infiltration of solid tumors. They show that CCL5 is ...

A variant form of LGL leukemia involves a specific T cell called CD8+. CD8+ T cells are T cells that carry the co-receptor CD8. A co-receptor is a surface protein that makes antigen receptors more ...

Researchers have found that antigen-specific killer T cells (CD8+ T cells) rapidly expand in the lungs when primed by antigen-presenting lung-resident alveolar macrophages (AMs). This interaction ...

Study uncovers a pathogenic subset of memory T-cells that promote tissue inflammation and highlights a potential target for treating nasal polyps and other inflammatory airway diseases. Study ...