Complement factors C3a, factor Ba and C5b-9 were evaluated by ELISA or immunoblotting. B1/B2 receptor double knock-out and wild-type mice were injected with lipopolysaccharide from E. coli B5:O55, to ...

本研究旨在比较胶质母细胞瘤患者（GBMPs）血液中循环 sEVs 中基质金属蛋白酶（MMP2 和 MMP9）、终末补体复合物（C5b-9）以及 VEGF-A 的水平，研究对象包括无肿瘤复发的患者（超过一年，n = 6）和首次复发的患者（n = 14）。通过差速超速离心法从血液样本中分离出 ...

for sCR1 abrogated the binding of C3 fragments to human sperm and fully protected sperm from C5b-9-mediated sperm immobilization. Moreover, CR1 inhibited ASA- and complement-mediated neutrophil ...

Unlike upstream blockers e.g. anti-C5, vilobelimab does not alter the membrane attack complex (C5b-9). Thus, vilobelimab leaves the formation of the C5b-9 intact as an important defense mechanism of ...

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IgA肾病新药有重大新进展！

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In some cases, C5 cleavage and terminal complement cascade reactions may occur, resulting in the formation of the membrane attack complex (C5b-9, MAC) and intravascular hemolysis (5). In this case, ...

2025年3月13日，就在今天，我们迎来了第20个世界肾脏日，今年的主题为“您的肾脏还好吗？早检查，保健康！”。今天小编带您了解一种超罕见的慢性原发性肾小球肾炎，C3肾小球病（C3G）。目前，随着研究的深入，临床对于C3G疾病概况、诊断和治疗策略有了 ...

Notably, microglia spatially associated with amyloid plaques exhibited increased expression of TREM2 and ApoE compared to ...